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In states of obesity and metabolic dysfunction, NNMT is often overexpressed in adipose tissue, depleting nicotinamide and reducing NAD+ availability [2]

While the exact mechanism remains debated, clinical observations suggest that B12 supplementation reduces nausea severity in a subset of users

IPA exerts microbiota-independent barrier protection in colitis and extends to multiple injury models To determine whether IPA-mediated barrier protection requires microbiome involvement, GF mice were administrated with IPA (GF-IPA) orally prior to DSS challenge (Supplementary Fig